Microbial Transformation of Two Prenylated Naringenins.
10.20307/nps.2017.23.4.306
- Author:
Fubo HAN
1
;
Ik Soo LEE
Author Information
1. College of Pharmacy and Research Institute of Drug Development, Chonnam National University,Gwangju 61186, Republic of Korea. islee@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Microbial transformation;
6-(1,1-dimethylallyl)naringenin;
5-(O-prenyl)naringenin-4′;
7-diacetate;
Mucor hiemalis;
Cunninghamella elegans var. elegans;
Penicillium chrysogenum
- MeSH:
Cunninghamella;
Fermentation;
Fungi;
Mucor;
Penicillium chrysogenum
- From:Natural Product Sciences
2017;23(4):306-309
- CountryRepublic of Korea
- Language:English
-
Abstract:
Microbial transformation of (±)-6-(1,1-dimethylallyl)naringenin (6-DMAN, 1) and (±)-5-(O-prenyl) naringenin-4′,7-diacetate (5-O-PN, 2) was performed by using fungi. Scale-up fermentation studies with Mucor hiemalis, Cunninghamella elegans var. elegans, and Penicillium chrysogenum led to the isolation of five microbial metabolites. Chemical structures of the metabolites were determined by spectral analyses as (±)-8-prenylnaringenin (3), (2S)-5,4′-dihydroxy-7,8-[(R)-2-(1-hydroxy-1-methylethyl)-2,3-dihydrofurano]flavanone (4), (±)-5-(O-prenyl)naringenin-4′-acetate (5), (±)-naringenin-4′-acetate (6), and (±)-naringenin (7), of which 5 was identified as a new compound.
