Detection of interleukin-17 and tumor necrosis factor-alpha and synovium pathological changes in patients with rheumatoid arthritis and significance
10.3760/cma.j.issn.1673-4904.2012.02.005
- VernacularTitle:类风湿关节炎血清白细胞介素17和肿瘤坏死因子α及滑膜病变检测的意义
- Author:
Wenli ZHANG
;
Hui LI
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Interleukin-17;
Tumor necrosis factor-alpha;
Synovium pathological changes
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(2):14-16
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the levels of serum interleukin -17(1L-17) and tumor necrosis factor -alpha( TNF- α ) and synovium pathological changes in patients with rheumatoid arthritis ( RA ) and its clinical significance.MethodsThe levels of serum IL-17 and TNF- α in 50 patients with active phase of RA ( active phase of RA group),50 patients with stable phase of RA ( stable phase of RA group ) and 50 normal controls (NC group) were measured by enzyme-linked immunospecific assay(ELISA),and the synovium was detected by pathological examination.ResultsThe levels of serum IL- 17 and TNF- α in active phase of RA group [(42.60 ± 11.30),( 113.20 ± 13.11 ) mg/L]were significantly higher than those in stable phase of RA group [( 19.60 ± 5.75),( 14.50 ± 5.33) mg/L]and NC group [(7.40 ± 3.32),( 10.90 ± 2.24 ) mg/L](P ＜0.01 ),the level of serum IL-17 in stable phase of RA group was significantly higher than that in NC group ( P ＜ 0.05),but the level of TNF- α had no significant difference between stable phase of RA group and NC group ( P ＞ 0.05).The synovium was significantly different between RA patients and NC group.Conclusion IL-17 and TNF-α are more sensitive index for detecting the activity of RA and may play important rolesinmonitoring the therapeutic effects and prognosis of RA.
