Effects of ARB and β-blocker in heart function and left ventricular remodeling of Dilated Cardiomyopathy

VernacularTitle:厄贝沙坦与比索洛尔对扩张型心肌病心功能及左室重构的影响
Author: Ruiming RAN ; Ping CHEN ; Guangdong SHI ; Zhongming KANG ; Dahe DENG
Publication Type:Journal Article
Keywords: Irbesartan; Bisoprolol; Cardiomyopathy,congestive; Heart failure; Left ventricular remodeling
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(1):38-39
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the effects of ARB or/and β-blocker in treatment of dilated cardiomyopathy(DCM).Methods95 cases with DCM were randomly divided into 3 groups.ARB group(A,32 cases) was treated with Irbesartan,150 mg/d without adverse drug reaction and then to 300 mg/d weekly; β-blocker group( B,30cases) was treated with Bisoprolol,1.25 mg/d without adverse drug reaction and then to maximal dose weekly; combination group( AB,33 cases) was treated with Irbesartan and Bisoprolol to maximal dose which patients were able to tolerate.The 3 groups were observed for a period of 12 months.ResultsComparing with pretreatment,the results of 6min walk,LVEDd,LVESd,LVEF were improved significantly( all P ＜0.05).There were no significant differences between A group and B group(P ＞0.05),but the differences between combination group and A group or B group were significant( P ＜0.05 ).ConclusionEffect of ARB combined with β-blocker was better than that of ARB or β-blocker alone in treatment of DCM and well tolerated.