Expression of RUNX3 mRNA in primary liver cancer and its clinical significance
10.3760/cma.j.issn.1007-8118.2012.01.009
- VernacularTitle:RUNX3基因在肝癌组织的mRNA表达水平及其临床意义
- Author:
Yanhui LU
;
Jianguo LI
;
Xiaojie JIANG
- Publication Type:Journal Article
- Keywords:
Liver cancer;
Tumor suppressor gene;
RUNX3 gene;
mRNA
- From:
Chinese Journal of Hepatobiliary Surgery
2012;18(1):30-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of RUNX3 mRNA in primary liver cancer (PHC) tissue and its surrounding normal tissue,and its clinical significance.MethodsReverse transcription polymerase chain reaction (RT-PCR) was performed to detect the expression of RUNX3 mRNA in tumor and peritumor tissues in 51 patients with PHC.The relationship between RUNX3 mRNA expression and some clinical pathological parameters was analyzed.ResultsThe relative expression values of RUNX3 mRNA in the tumor tissue and the surrounding normal tissue were 0.4509±0.0963 and 0.9147± 0.0222,respectively.The difference was significant (t=33.6087,P＜0.001).The RUNX3 mRNA expression in tumor tissue correlated with some clinical pathological parameters including low tumor differentiation,positive cancer embolus and intrahepatic invasion and metastasis.The RUNX3 mRNA expression was not correlated with other clinicopathological parameters including gender,cancer diameter,cancer location,hemorrhage and necrosis of cancer,and histotype.ConclusionRUNX3 may be a new tumor suppressor gene for PHC.
