Expression of AKT2 gene in human liver cancer and its clinical significance
10.3760/cma.j.issn.1007-8118.2012.01.011
- VernacularTitle:肿瘤基因AKT2在肝癌中的表达及其临床意义
- Author:
Yi XIE
;
Xin CHEN
;
Haixin QIAN
;
Wanghe WANG
;
Chao ZHANG
- Publication Type:Journal Article
- Keywords:
Liver cancer;
Oncogene,AKT2;
immunohistochemistry;
Polymerase chain reaction
- From:
Chinese Journal of Hepatobiliary Surgery
2012;18(1):34-36
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the expression of AKT2 gene in liver cancer and its relationship to tumor progression.MethodsThe expression of AKT2 in liver cancer was detected by SP immunohistochemical stainin and reverse transcription polymerase chain reaction (RT-PCR).Four patients with benign liver tumors were used as control.ResultsThe positive rates of AKT2 in liver cancer tissue and benign control tissue were 62.5％ (28/32) and 0％ (0/4),respectively.The difference was significant.In addition,a positive expression of AKT2 correlated significantly with poor differentiation,positive lymph node and distant metastasis.The median survival after surgery was significantly shorter in patients with positive than with negative AKT2 (76d vs 463d).ConclusionThe detection of AKT2 was useful in assessing the progression of liver cancer,in determining prognosis and eventually in rendering a possible target for novel therapeutic strategies.
