Expressions of CD90 and hTERT in hepatocellular carcinoma and Their Clinical Significance
10.3760/cma.j.issn.1007-8118.2012.01.012
- VernacularTitle:干细胞表面标志物CD90及端粒酶逆转录酶在原发性肝癌中的表达及临床意义
- Author:
Yewei ZHANG
;
Jian NIU
;
Hewei ZHAO
;
Wen WANG
;
Dongliang YAN
;
Xuehao WANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Tumor stem cell;
CD90;
Human telomerase reverse transcriptase
- From:
Chinese Journal of Hepatobiliary Surgery
2012;18(1):37-39
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the expressions of CD90 and hTERT in hepatocellular carcinoma (HCC),and their relationships to progression of tumor.MethodsThe expressions of CD90 and hTERT in hepatocellular carcinoma were detected by S-P immunohistochemical staining.Twenty patients with hemangiomas of liver were used as control.ResultsCompared with the control group,the positive rates of CD90 and hTERT in HCC were significantly higher (63.9％ and 47.2％ vs 0％ and 0％).The positive rates of CD90 and hTERT were significantly higher in patients with tumors at UICC Ⅲ-Ⅳ stage than at UICC stage Ⅰ -Ⅱ (79.1％ and 62.5％ vs 33.3％ and 16.6％).The CD90 expression correlated with hTERT positively.There were significant differences in survival between patients with CD90+ and CD90- or hTERT+ and hTERT-.The median postoperative survivals for patients with CD90+ and hTERT+,CD90- and hTERT- were 85 d and 76 d,505 d and 463 d,respectively.ConclusionsCD90 expression correlated positively with progression of HCC.It has the potential to serve as a prognostic marker for HCC.
