Association between rs1512268 single nucleotide polymorphism of NKX3.1 gene and the risk of prostate cancer: a preliminary study
10.3760/cma.j.issn.0254-9026.2012.01.011
- VernacularTitle:NKX3.1基因rs1512268单核苷酸多态性与前列腺癌风险关系的初步研究
- Author:
Xiaohong SHI
;
Jianye WANG
;
Ming LIU
;
Dong WEI
;
Changhu ZHOU
;
Yaoguang ZHANG
;
Ze YANG
- Publication Type:Journal Article
- Keywords:
Prostate neoplasms;
Genes;
Polymorphism,single nucleotide
- From:
Chinese Journal of Geriatrics
2012;31(1):29-32
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the association between the common variant rs1512268 single nucleotide polymorphism(SNP) of NKX3.1 gene and the risk of prostate cancer,and to explore its interaction with related risk factors.MethodsTotally 122 patients with prostate cancer and 105 age matched male people (prostatic specific antigen ＜ 4 μg/L,without family history of prostate cancer) as control group were enrolled.Polymerase chain reaction - high resolution melting curve(PCR - HRM) combined with gene sequencing methods were used to determine the distribution of allele and genotype frequencies of the rs1512268 SNP.ResultsThe distributions of GG,AG,AA genotypes were 42 cases(33.4％),66 cases(54.1％),14 cases(11.5％) in patients with prostate cancer,and 45 cases(42.9％),51 cases(48.6％),9 cases(8.6％) in healthy control,respectively.There were no significant differences in the distribution of genotype(x2 =1.70,0.69,0.52) and allele frequency (x2 =1.575) between the two groups(P＞ 0.05).The different genotypes of rs1512268 of NKX3.1 gene were not associated with age,Gleason score,PSA levels and clinical stage of prostate cancer (P＞0.05). Conclusions rs1512268 SNP of NKX3.1 gene is not obviously associated with prostate cancer and may be not the genetic risk factor in Chinese.
