Changes of plasma nesfatin-1 levels in patients with impaired glucose regulation and type 2 diabetes mellitus
10.3760/cma.j.issn.1000-6699.2012.01.009
- VernacularTitle:糖调节受损和2型糖尿病患者血浆nesfatin-1水平的变化
- Author:
Jing SU
;
Fei YE
;
Zhiyong LI
;
Gangyi YANG
;
Wei ZHU
;
Ling LI
;
Wenjuan QU
;
Dandong WU
;
Zhihong ZHANG
- Publication Type:Journal Article
- Keywords:
Nesfatin-1;
Insulin resistance;
Impaired glucose regulation;
Diabetes mellitus,type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(1):26-28
- CountryChina
- Language:Chinese
-
Abstract:
Plasma nesfatin-1 levels were assayed by ELISA in patients with impaired glucose regulation (IGR),type 2 diabetes mellitus( T2DM ),and healthy subjects with normal glucose tolerance( control group).The results showed that plasma nesfatin-1 levels in IGR and T2DM groups were significantly higher than that in control group [ ( 1.91 ±0.79 and 1.80±0.80 vs 1.41 ±0.58) μg/L,P<0.01 ].Plasma nesfatin-1 levels were positively correlated with body mass index(BMI),HbA1c,waist hip ratio,fasting plasma glucose,fasting insulin,and homoestasis model assessment insulin resistant index( HOMA-IR,P<0.05 or P<0.01 ).Multiple regression analysis showed that BMI and HOMA-IR were independent related factors in influencing plasma nesfatin-1 levels (both P<0.01 ).These results suggest that nesfatin-1 may partially contribute to the pathogenesis of insulin resistance and T2DM.