Changes of plasma nesfatin-1 levels in patients with impaired glucose regulation and type 2 diabetes mellitus

VernacularTitle:糖调节受损和2型糖尿病患者血浆nesfatin-1水平的变化
Author: Jing SU ; Fei YE ; Zhiyong LI ; Gangyi YANG ; Wei ZHU ; Ling LI ; Wenjuan QU ; Dandong WU ; Zhihong ZHANG
Publication Type:Journal Article
Keywords: Nesfatin-1; Insulin resistance; Impaired glucose regulation; Diabetes mellitus,type 2
From: Chinese Journal of Endocrinology and Metabolism 2012;28(1):26-28
CountryChina
Language:Chinese
Abstract: Plasma nesfatin-1 levels were assayed by ELISA in patients with impaired glucose regulation (IGR),type 2 diabetes mellitus( T2DM ),and healthy subjects with normal glucose tolerance( control group).The results showed that plasma nesfatin-1 levels in IGR and T2DM groups were significantly higher than that in control group [ ( 1.91 ±0.79 and 1.80±0.80 vs 1.41 ±0.58) μg/L,P＜0.01 ].Plasma nesfatin-1 levels were positively correlated with body mass index(BMI),HbA1c,waist hip ratio,fasting plasma glucose,fasting insulin,and homoestasis model assessment insulin resistant index( HOMA-IR,P＜0.05 or P＜0.01 ).Multiple regression analysis showed that BMI and HOMA-IR were independent related factors in influencing plasma nesfatin-1 levels (both P＜0.01 ).These results suggest that nesfatin-1 may partially contribute to the pathogenesis of insulin resistance and T2DM.