Acetyl-CoA carboxylase expression in the liver of quail with hyperuricemia and abdominal obesity
10.3760/cma.j.issn.1000-6699.2012.01.021
- VernacularTitle:乙酰辅酶A羧化酶在高尿酸血症合并腹型肥胖鹌鹑肝脏中的表达
- Author:
Zhijian LIN
;
Bing ZHANG
;
Xiaoqing LIU
- Publication Type:Journal Article
- Keywords:
Acetyl-CoA carboxylase;
Hyperuricemia;
Abdominal obesity;
High purine diet;
Quail
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(1):73-75
- CountryChina
- Language:Chinese
-
Abstract:
The quail model of hyperuricemia combined with abdominal obesity was induced by high purine diet.Body weight in model group showed no change.Serum uric acid level in model group was increased significantly on 7,14,21,and 28 d( P＜0.05 or P＜0.01 ).Abdominal fat index in model group increased significantly on 28d.On 7 d and 28 d,serum free fatty acid level was increased significantly.Acetyl-CoA carboxylase( ACC ) protein expression in the liver of model quail was increased as shown by ELISA and immunohistochemisty ( P＜0.05 or P＜0.01 ),suggesting that the alteration of ACC expression contributes to the pathogenesis of hyperuricemia combined with abdominal obesity.
