PKC θ expression in gastrointestinal stromal tumors
10.3760/cma.j.issn.1007-631X.2012.01.013
- VernacularTitle:蛋白激酶Cθ在胃肠道间质肿瘤中的表达及意义
- Author:
Xiaodong YANG
;
Zhiqiang WANG
;
Lingyi DONG
;
Hui ZHANG
;
Yingjiang YE
;
Shan WANG
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumors;
Protein kinase C;
Tumor markers,biological
- From:
Chinese Journal of General Surgery
2012;27(1):34-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate protein kinase Cθ(PKCθ)for the differential diagnosis of gastrointestinal stromal tumors(GIST).Methods The expression pattern of PKC θ was detected by immunohistochemistry in 121 GISTs,paired 51 distant normal tissues and 70 non-GIST sarcomas.Results Immunoreactivity for PKC θ was detected in 111 of 121 GIST cases,all eight CDll7-negative GISTs were PKC θ positive.PKC θ was negative in all distant normal tissue samples and 26 smooth muscle tumors.The positive expression rate of gastrointestinal mesenchemal tumors other than GIST was 18.2％.The expression rate of PKC θ did not vary with of tumor location,cell morphology and risk grades.Conclusions PKC θ could be a potential diagnotic marker in GIST patients,especially in those with negative CD117.
