Pretreatment of dialyzer with high-dose vitamin C reduces oxidative stress of patients withhemodialysis
10.3760/cma.j.issn.1671-7368.2012.01.025
- VernacularTitle:大剂量维生素C预冲透析器联合维生素E和丹参对血液透析患者晚期氧化蛋白产物的影响
- Author:
Yinan LI
;
Yanlin ZHANG
;
Linghui ZHOU
;
Qiuyue CHEN
;
Jun ZHANG
;
Hengyuan ZHANG
;
Weiping HU
- Publication Type:Journal Article
- Keywords:
Renal dialysis;
Oxidative stress
- From:
Chinese Journal of General Practitioners
2012;11(1):59-61
- CountryChina
- Language:Chinese
-
Abstract:
Sixty patients who had hemodialysis over half year were randomly divided into 3 groups with 20 cases in each group:group A received conventional hemodialysis,group B received hemodialysis with oral administration of compound danshen (salvia miltiorrhiza bunge) tablets and vitamin E,group C had the same treatment as group B but the dialyzer was pretreated with solution containing 5 g vitamin C ; 20 healthy adults served as normal controls. Serum levels of advanced oxidation protein products (AOPP) and superoxide dismutase (SOD) were measured in all groups.The levels of AOPP in groups A,B,C were higher and SOD levels were lower than those of normal controls ( all P ＜ 0.01 ).The levels of AOPP in groups B,C were lower and SOD were higher than those in group A at the same time points (P ＜0.01 ).The levels of AOPP in group C were lower and SOD were higher than those in group B at the same time points (P ＜0.0l ).The results suggest that pretreatment of the dialyzer with high dose vitamin C plus vitamin E and compound danshen tablets can alleviate oxidative stress in patients with maintaining hemodialysis.
