Effects of Telmisartan on the expression of Toll-like receptor 4 in monocytes of ApoE-deficient mice
10.3760/cma.j.issn.0254-9026.2012.01.022
- VernacularTitle:替米沙坦对ApoE基因缺陷小鼠单核细胞Toll样受体4表达的影响
- Author:
Xiaoyong GENG
;
Mingzhao QIN
;
Bingying NIU
- Publication Type:Journal Article
- Keywords:
Toll-like receptor 4;
Atherosclerosis;
Monoeytes;
Mice,knockout
- From:
Chinese Journal of Geriatrics
2012;31(1):68-70
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effects of telmisartan on toll-like receptor (TLR) 4 expression in monocytes of mice atherosclerosis (AS)model, and explore the mechanism of inflammation.MethodsAS mice model were established in ApoE-deficient mice fed with high-fat diet,and treated with telmisartan as intervention group. After 8 weeks, serum low density lipoprotein,triacylglycerol and total cholesterol were detected in group fed with high-fat diet and intervention group.TLR 4 expressions in two groups were analyzed by flow cytometry. Results There was no significant difference in levels of blood lipids between the two groups.TLR4 expression in monocytes in telmisartan intervention group was lower than group fed with high-fat diet (P＜0.05).ConclusionsTelmisartan may intervene the inflammation during atherosclerosis by downregulating TLR4 expression in monocytes.
