Diagnosis and treatment of early-stage hepatic artery thrombosis after adult liver transplantation
10.3760/cma.j.issn.1007-8118.2012.01.006
- VernacularTitle:成人肝移植术后早期肝动脉血栓形成的诊断与治疗
- Author:
Weiqiang JU
;
Xiaoshun HE
;
Zhiyong GUO
;
Linwei WU
;
Qiang TAI
;
Dongping WANG
;
Xiaofeng ZHU
;
Jiefu HUANG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Hepatic artery thrombosis;
Doppler ultrasound screening;
Interventional therapy
- From:
Chinese Journal of Hepatobiliary Surgery
2012;18(1):19-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnosis and treatment of early-stage hepatic artery thrombosis(HAT) after adult liver transplantation.Methods387 consecutive adult patients who underwent liver transplantation from June 2007 to October 2010 by the same surgery team in the Transplant Center,First Affiliated Hospital of Sun Yat-sen University were retrospectively studied.Hepatic arterial blood flow was monitored by color Doppler ultrasound (DUS) daily during the first week after transplantation.Ultrasonic contrast or hepatic artery angiography was performed on recipients with suspected HAT.Results10 patients developed HAT on 7(2-18)d after operation.The incidence of HAT was 2.6％ (10/387).Interventional therapy was performed in 2 patients with one patient who received a stent because of hepatic artery stricture.Three patients underwent emergent hepatic artery revascularization combined with intra-arterial urokinase thrombolysis treatment.One developed a rethrombosis and died.The remaining 2 patients received re-transplantation.Three patients died of liver failure and severe infection.The mortality rate was 40％ (10/387).ConclusionsIt is essential to diagnoses HAT by monitoring the artery flow by Doppler ultrasound screening in the early period after operation.Interventional therapy,emergent hepatic artery revascularization and re-transplantation are effective rescue treatments.Prevention of HAT is most important.
