The roles of heat shock protein 27 in cerebral ischemic tolerance
10.3760/cma.j.issn.1673-4165.2011.12.015
- VernacularTitle:热休克蛋白27在脑缺血耐受中的作用
- Author:
Baoxing WU
;
Pingping ZHU
;
En XU
- Publication Type:Journal Article
- Keywords:
Heat-shock proteins;
Brain ischemia;
Ischemic preconditioning,Apoptosis
- From:
International Journal of Cerebrovascular Diseases
2011;19(12):948-952
- CountryChina
- Language:Chinese
-
Abstract:
Heat shock protein 27 is one of the members of the small heat shock protein family.Its molecular chaperone function and the interaction with the cell death pathway mediate cell survival under the stress state.The expression of heat shock protein 27 in ischemic lesions and remote areas and its changes in phosphorylation levels during cerebral ischemia is associated with neuronal tolerance to ischemia.However,the neuroprotective mechanism of heat shock protein 27 in cerebral ischemic tolerance still remains unclear.This article reviews the roles of heat shock protein 27 in cerebral ischemic tolerance and its potential mechanism.
