The effect of astragalus polysaccharides on androgen excess within ovarian granulosa cells of PCOS patients in vitro
10.3760/cma.j.issn.1008-1372.2011.12.007
- VernacularTitle:黄芪多糖对体外培养多囊卵巢综合征患者卵巢颗粒细胞雄激素分泌异常的影响
- Author:
Yajuan ZHANG
;
Min SANG
;
Hongxiu ZHANG
;
Linan LI
;
Huiming LV
;
Yuan AN
- Publication Type:Journal Article
- Keywords:
ASTRAGALAN /PD;
Polycystic ovary syndrome/DT/ME;
Ovary/CY/ME;
Androgens/ME
- From:
Journal of Chinese Physician
2011;13(12):1607-1610
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study androgen excess within ovarian granulosa cells of PCOS patients in vitro,and the partial improvement by using astragalus polysaccharides.MethodsOvarian granulosa cells from the PCOS patients during IVF / ICSI - ET were isolated and cultured in vitro,then it was treated by different concentrations of astragalus polysaccharides.The levels of estradiol,progesterone and testosterone were determined.ResultsAndrogen secretion within ovarian granulosa cells from PCOS patients was significantly increased [ ( 0.4716 ± 0.03 ) nmol/L,( 0.23 ± 0.0162 ) nmol/L,P ＜ 0.05 ].The levels of estradiol and progesterone were not significantly different( P ＞ 0.05 ).Different concentrations of astragalus polysaccharides may result from the alleviation of androgen secretion which was commonly found in PCOS treatment (concentration was 1000 μg/ml,100 μg/ml,50 μg/ml,P ＜ 0.01 ;concentration was 500 μg/ml,P =0.002 ; concentration was 200 μg/ml,P =0.003).ConclusionsAstragalus polysaccharides inhibit the secretion of testosterone in granulosa cells of PCOS patients during in vitro,and it may be an alternative treatment for PCOS.
