Toll-like receptor 4 signalling pathway in microglia and central nervous system injury
10.3760/cma.j.issn.1673-4165.2011.12.014
- VernacularTitle:小胶质细胞Toll样受体4信号转导通路与中枢神经系统损伤
- Author:
Zhenquan SUN
;
Yongmei ZHANG
- Publication Type:Journal Article
- Keywords:
Microglia;
Toll-like receptor 4;
Inflammation;
Central nervous system diseases
- From:
International Journal of Cerebrovascular Diseases
2011;19(12):944-947
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of central nervous system injury is complex.Microglia cells participate in a variety of central nervous system diseases and damage processes.Toll-like receptor 4 (TLR4) mediates the microglial activation and the expression of inflammatory cytokines.It is one of the important receptor proteins for microglia cells performing their functions.This article briefly introduces the role of TLR4 signal pathway in the central nervous system injury.
