The impact of nucleos(t)ide analogue antiviral therapy on anxiety and depression of patients with chronic hepatitis B
10.3760/cma.j.issn.1000-6680.2011.12.005
- VernacularTitle:核苷(酸)类似物抗病毒治疗对慢性乙型肝炎患者焦虑和抑郁状态的影响
- Author:
Shuangshuang XIE
;
Qiang LI
;
Xia YANG
;
Wenbo FAN
;
Jinhong YU
;
Li LIU
;
Wenwen LI
;
Shijun CHEN
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
Nucleotides;
Anxiety;
Depressive disorder;
Manifest anxiety scale;
Mental status schedule
- From:
Chinese Journal of Infectious Diseases
2011;29(12):723-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of nucleos(t)ide analogue antiviral therapy on anxiety and depression of patients with chronic hepatitis B (CHB),and analyze the related factors.Methods Before nucleos(t)ide analogue antiviral therapy,1 year and 2 years after antiviral therapy,120 CHB patients were investigated with self-rating anxiety scale (SAS) and self-rating depression scale (SDS).The demography data of patients were collected.Serum levels of alanine transaminase (ALT) and hepatitis B virus (HBV) DNA and other biochemical indicators were measured regularly.Results Before nucleos(t)ide analogue antiviral therapy,1 year and 2 years after antiviral therapy,both the mean scores of SAS and SDS became lower gradually (F=12.661 and 22.395,respectively;both P＜0.01).The percentage of patients with SAS and SDS scores more than 50 were 5.8％,4.2％,1.7％ and 13.3％,7.5％,5.0％,respectively.After 2 years of therapy,the anxiety improvement rate of the patients obtained HBV DNA＜1000 copy/mL was 69.0％,while those with HBV DNA≥1000 copy/mL was 22.2％ (x2 =22.325,P＜0.01).Meanwhile,after 2 years of therapy,the depression improvement rate of the patients obtained HBV DNA＜1000 copy/mL was 77.4％,while those with HBV DNA≥1000 copy/mL was 22.2％ (x2 =32.179,P＜0.01).Multiple factors Logistic regression analysis indicated that the odds ratios (OR) of improvement of anxiety and depression in patients with HBV DNA＜1000 copy/mL were 7.751 (95％ CI:3.026-19.853) and 15.069(95％ CI:5.309-42.770),respectively,compared with those with HBV DNA≥1000 copy/mL; and OR of improvement of depression in patients with ALT≤40 U/L waa 4.103 (95％ CI: 1.376 - 12.238).Conclusions Nucleos(t) ide analogue antiviral therapy could improve the anxiety and depression of CHB patients.The HBV DNA negativity is the independent impact factor of improvement of anxiety and depression in CHB the patients.
