Effects of sepsis on pharmacodynamics of rocuronium in rats
10.3760/cma.j.issn.0254-1416.2011.11.027
- VernacularTitle:脓毒血症对大鼠罗库溴铵药效学的影响
- Author:
Mengbi JIANG
;
Su MIN
;
Jie LUO
;
Jingyan LIN
;
Wei LI
;
Bin WANG
- Publication Type:Journal Article
- Keywords:
Sepsis;
Androstanlos;
Dose-response relationship,drug
- From:
Chinese Journal of Anesthesiology
2011;31(11):1384-1386
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of sepsis on pharmacodynamics of rocuronium in rats.MethodsForty SD male rats weighing 250-350 g were randomly divided into 3 groups: control group(group C,n =10) ; sham operation group(group S,n =10)and sepsis group (group Sep,n =20).Cerum was ligated and perforated to produce sepsis model in Sep group,rocuronium 3.81 mg/kg was intravenously injected at 6 or 16 h after operation,each time contains 10 rats.Cecum was not ligate and perforate in group S,but rocuronium 3.81 mg/kg was intravenously injected at 6 h after operation.Onset time,TOF no reaction period,duration of peak effect,clinical duration,totel duration,time for recovery of T1 to 10%,25%,50%,75%,90% and recovery index were recorded by RM6240B signal acquisition and processing system.ResultsCompared with groups C and S,onset time was significantly prolonged,TOF no reaction period,duration of peak effect,clinical duration,total duration and time for recovery T1 to 10%,25%,50%,75%,90% and recovery index were shortened in group Sep ( P < 0.05).Onset time was significantly prolonged,time for recovery of T1 to 75% was shortened when rocuronium injection at 16 h after operation as compared with that at 6 h after operation in group Sep( P < 0.05).ConclusionSepsis can attenuate the effects of nondepolarizing neuromuscular blocker rocuronium,the degree is related to the stage of sepsis.