Preventive efficacy of NMDA receptor antagonists on remifentanil-induced postoperative hyperalgesia: a Meta- analysis
10.3760/cma.j.issn.0254-1416.2011.10.002
- VernacularTitle:NMDA受体拮抗剂预防瑞芬太尼诱发术后痛觉过敏的效果:Meta分析
- Author:
Yue LIU
;
Yaguo ZHENG
;
Xiaoping GU
;
Zhengliang MA
- Publication Type:Journal Article
- Keywords:
Receptors,N-mmethyl-D-aspartate;
Piperidines;
Hyperalgesia;
Meta-analysis
- From:
Chinese Journal of Anesthesiology
2011;31(10):1170-1174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically review the preventive efficacy of N-methyl-D-aspartate (NMDA) receptor antagonists on remifentanil-induced postoperative hyperalgesia.Methods Pubmed,EMBase,Springer and Cochrane Controlled Trials Register were searched to identify all randomized controlled trials(RCTs) about efficacy of NMDA receptor antagonists for preventing remifentanil-induced postoperative hyperalgesia.The quality of the studies was evaluated by the method recommended by Cochrane Collaboration.The data was extracted,including postoperative analgesic consumption,pain scores,time for first analgesic request and the incidence of adverse effects.Meta-analysis was conducted using the Cochrane Collaboration's RevMan 5.0 software.Results Fourteen RCTs involving 623 patients were included in our Meta-analysis.NMDA receptor antagonists significantly decreased pain scores at 4 h after operation ( P ＜ 0.05),and had no effect on postoperative analgesic consumption,time for first analgesic request and the incidence of adverse effects ( P ＞ 0.05).Conclusion NMDA receptor antagonists (ketamine and magnesium)can not prevent the occurrence of postoperative hyperalgesia induced by remifentanil.
