Effect of shenfu injection on airway resistance and oxygenation during one-lung ventilation in patients undergoing lobectomy
10.3760/cma.j.issn.0254-1416.2011.11.007
- VernacularTitle:参附注射液对肺叶切除术患者单肺通气期间气道阻力和氧合功能的影响
- Author:
Xiaozheng LI
;
Shiduan WANG
;
Jieping LI
;
Qiang WANG
;
Yan JIANG
;
Haifang YU
;
Yun ZHANG
- Publication Type:Journal Article
- Keywords:
SHENFU DECOCTION;
Respiration,artificial;
Pneumonectomy;
Airway resistance;
Pulmonary gas exchange
- From:
Chinese Journal of Anesthesiology
2011;31(11):1313-1315
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the effect of shenfu injection on airway resistance and oxygenation during one-lung ventilation (OLV) in patients undergoing lobectomy.MethodsSixty ASA Ⅱ patients of both sexes,aged 50-80,BMI 20-29 kg/m2,scheduled for lobectomy under thoracic epidural block combined with general anesthesia,were randomly divided into 2 groups( n =30 each):normal saline control group (group C) and shenfu injection group (group S).In group S,shenfu injection was infused intravenously at 4.5 ml·kg-1 ·h-1 for 20 min before anesthesia induction.In group C,equal volume of normal saline was infused instead of shenfu injection.Airway peak pressure was recorded and arterial blood samples were taken for determination of PaO2 before OLV,at 30,60 min of OLV and the end of surgery.Oxygenation index was calculated.ResultsCompared with group C,airway peak pressure was significantly decreased and oxygenation index increased at 30,60 min of OLV in group S ( P ＜ 0.05).ConclusionShenfu injection can decrease airway resistance and increase oxygenation during OLV in patients undergoing lobectomy,indicating that shenfu injection has a lung-protective effect.
