Patterns of recurrence and prognostic factors of disease free survival in penile squamous cell carcinoma treated with lymphadenectomy
10.3760/cma.j.issn.1000-6702.2011.12.003
- VernacularTitle:阴茎鳞状细胞癌淋巴结清扫术后复发类型及预后因素分析
- Author:
Yao ZHU
;
Xiaoyan ZHOU
;
Xudong YAO
;
Bo DAI
;
Hailiang ZHANG
;
Dingwei YE
- Publication Type:Journal Article
- Keywords:
Penile neoplasms;
Carcinoma;
Lymph node excision;
Prognosis;
Disease-freesurvival
- From:
Chinese Journal of Urology
2011;32(12):799-802
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the recurrence patterns and possible prognostic factors in primary penile cancer treated with penectomy and standard lymphadenectomy.Methods The records of 73 patients with penile squamous cell carcinoma who underwent penile amputation and regional lymphadenectomy between 1990 and 2005 were reviewed.The median follow up was 32 ( 16 - 183) months.Molecular markers including p53 and Ki-67 were detected using immunohistochemistry.Recurrence patterns,pathological characteristics,and patient outcomes were analyzed.ResultsTwenty( 27.4％ ) patients developed recurrences at a mean of 11 (6 - 17 ) months postoperatively and 3 cases remained alive at last follow-up.The mean cancer specific survival of the recurrent patients was 26 ( 16 - 83 ) months.Distant metastasis and multiple recurrences were common among patients with high-grade tumor (P =0.017 ).Univariate analysis revealed that higher primary tumor stage,higher pathological grade,lymph node metastasis,extra-nodal involvement and positive p53 protein expression were significantly associated with decreased 3-year disease free survival rates.Cox regression identified that only pathological grade ( P =0.025 ) and lymph node status ( P =0.024 ) were independent predictors of disease free survival.ConclusionsPathological grade and lymph node status were independent predictors of disease free survival in patients with penile squamous cell carcinoma in this cohort.Patients with high-grade disease are likely to recur in a distant or multiple pattern.
