Construction of a nomogram to predict disease free survival in node-positive penile cancer treated with surgery
10.3760/cma.j.issn.1000-6702.2011.12.007
- VernacularTitle:预测淋巴结阳性阴茎癌手术后无病生存率列线图的建立
- Author:
Jian LI
;
Yao ZHU
;
Xudong YAO
;
Shilin ZHANG
;
Bo DAI
;
Hailiang ZHANG
;
Yijun SHEN
;
Dingwei YE
- Publication Type:Journal Article
- Keywords:
Penile neoplasms;
Carcinoma;
Prognosis;
Survival analysis;
Nomogram
- From:
Chinese Journal of Urology
2011;32(12):807-810
- CountryChina
- Language:Chinese
-
Abstract:
Objective To construct a nomogram for estimating disease free survival of node-positive penile cancer treated with surgery.MethodsThe clinicopathological data of 32 node-positive penile squamous cell carcinoma patients were retrospectively reviewed.All patients had undergone primary tumor excision and regional lymphadenectomy.The pathological records showed that 10 were N1,13 were N2 and 9 were N3.Median level of preoperative squamous cell carcinoma antigen (SCCAg) was O.9 μg/L.With a median follow-up of 16.5 months,13 patients developed recurrence.Based on the stage,histological grade and preoperative serum squamous cell carcinoma antigen level,a nomogram was drawn on the basis of the Cox regression model.Results Stage and preoperative serum SCCAg levels were independent prognostic factors for disease free survival in node-positive penile cancer treated with surgery.The hazard ratio of SCCAg level and N stage was 2.76 (95％ CI:1.40-5.44,P=0.0034) and 28.51 (95％ CI:2.55 -319.11,P =0.0066).The nomogram demonstarted good discrimination and calibration with a concordance index of 0.855.Conclusions Based on the N stage and preoperative serum SCCAg level,a nomogram to predict disease free survival in node-positive penile cancer treated with surgery was set up.The prediction model could be helpful in predicting the risk of recurrence.
