Study on the pharmacokinetics of Qingkailing tablets in healthy body
10.3760/cma.j.issn.1673-4246.2011.12.018
- VernacularTitle:清开灵片中黄芩苷体内药代动力学研究
- Author:
Jieqi JU
- Publication Type:Journal Article
- Keywords:
Baicalin;
HPLC;
Pharmacokinetics
- From:
International Journal of Traditional Chinese Medicine
2011;33(12):1104-1106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a high performance liquid chromato-graphic method for determining the concentration of baicalin in healthy volunteers.Methods The assay was conducted on the Agilent HC-C18 (250 mm × 4.6 mm,5 μm)column with methanol-acetonitrile-phosphoric acid (47 ∶ 53∶0.2)as the mobile phase.The detection wave length was set at 280 nm,and wogonin was taken as the internal standard.Results The linearity range was 0.25～ 12.0 μg/ml with a regressive equation of Y=0.0094 C-0.00175 (r=0.9997).The recovery was above 80％,with both intra-day RSD and inter-day RSD below 10％.Conclusion The method was convenient,rapid,accurate,and suitable for the pharmacokinetic study of baicalin and monitoring its concentration of clinical application.
