Anterior pituitary hypofunction: a clinical analysis of 117 cases
10.3760/cma.j.issn.1000-6699.2011.11.004
- VernacularTitle:垂体前叶功能减退症117例临床分析
- Author:
He LIU
;
Hua JIANG
;
Cuiping CAO
;
Guoliang LIU
- Publication Type:Journal Article
- Keywords:
Anterior pituitary hypofunction;
Etiological factor;
Diagnosis
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(11):883-886
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical features of anterior pituitary hypofunction.Methods A retrospective analysis was carried out on the data of 117 patients with anterior pituitary hypofunction during 1994-2010.Results There were 60.68% male and 39.32% female patients respectively.The onset age was from 13 to 79 years,with 79.12% of the patients more than 40 years old.There were 57 cases with sellar tumors ( 40.17% ),in which 55 cases( 96.49% )were operated and (or) treated with radiotherapy.35 cases were operated via the frontal approaches( 66.04% ) and 18 cases underwent transsphenoidal surgery ( 33.96% ).There were 108 cases with hyponatremia with the first symptoms of weakness,anorexia,nausea,and vomiting induced by ACTH deficiency (92.31% ).There were 23 cases accompanied with central diabetes insipidus( 19.66% )and 82 cases with coronary heart disease( 70.09% ).Conclusion Owing to the difference in etiological factors,the incidence,early symptoms,and the hormones involved are greatly different.The main cause is pituitary tumor,which occured more in aged person,more in males than females.