Effect of simvastatin on toll-like receptor 4 expression in kidney of diabetic rats
10.3760/cma j.issn.1000-6699.2011.11.019
- VernacularTitle:辛伐他汀对糖尿病大鼠肾组织Toll样受体4表达的影响
- Author:
Jianping WANG
;
Li ZANG
;
Shijing ZHANG
;
Fangfang ZHAO
;
Jun ZHANG
;
Yang CHEN
;
Ting FU
;
Yiben YU
- Publication Type:Journal Article
- Keywords:
Simvastatin;
Toll-like receptor 4;
Diabetic nephropathy;
Inflammatory reaction
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(11):945-946
- CountryChina
- Language:Chinese
-
Abstract:
Immunohistocheraistry and RT-PCR were used to examine the expression of toll-like receptor 4 (TLR4) in the kidney of diabetic rats.Compared with normal control group,the expression of TLR4 in diabetes mellitus group was increased ( P ＜ 0.05 ).Compared with diabetes mellitus group,the expression of TLR4 in simvastatin treated group was decreased( P＜0.05 ).The results suggest that TLR4 may play a role in the pathogenesis of diabetic nephropathy.Simvastatin seems to delay the progress of diabetic nephropathy via reducing TLR4 expression.
