Combined liver-kidney transplantation and orthotopic liver transplantation in the treatment of severe hepatitis B
10.3760/cma.j.issn.1007-631X.2011.10.002
- VernacularTitle:重症肝炎行原位肝移植术及肝肾联合移植术的疗效比较
- Author:
Xiaosheng QI
;
Zhihai PENG
;
Guoqing CHEN
;
Junming XU
;
Lin ZHONG
;
Xing SUN
;
Yu FAN
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Liver transplantation;
Combined liver-kidney transplantation
- From:
Chinese Journal of General Surgery
2011;26(10):804-806
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare orthotopic liver transplantation (OLT)and combined liverkidney transplantation (CLKT) in the treatment of severe hepatitis B.MethodsIn this study 52 patients of severe hepatitis B were allocated to OLT (40 cases) or CLKT( 12 cases) at our department from Jan.2001 to Sep.2005.The perioperative complications and the result of follow-up were analyzed.ResultsThe preoperative renal functions in CLKT cases were severer than that in OLT cases.Postoperative severe infection was more common in CLKT cases than that in OLT cases.In OLT group 28 patients (70％)suffered from early posttransplant renal dysfunction,among them 11 patients needed dialysis,whilst there were 2 (16.7％ ) patients who needed dialysis in CLKT group (P ＜0.01 ).The posttransplant mortality in OLT group was 40％ ( n =16),significantly higher than that in CLKT ( 16.7％,n =2) ( P ＜ 0.01 ).In OLT group,9 cases developed severe renal failure and died.No one died of renal failure in CLKT group.ConclusionsThe prognosis is more favorable to perform CLKT in patients who suffered from severe hepatitis B with chronic renal dysfunction before transplantation.
