Qingpeng ointment in the treatment of eczema: a multi-center, randomized, double-blind, placebo controlled study
10.3760/cma.j.issn.0412-4030.2011.12.003
- VernacularTitle:青鹏软膏治疗湿疹的随机、双盲、对照多中心临床观察
- Author:
Hui TANG
;
Qinping YANG
;
Dan LUO
;
Qiuning SUN
;
Zaipei GUO
;
Dongning LI
;
Liyan XI
;
Jinhua XU
- Publication Type:Journal Article
- Keywords:
Eczema;
Controlled clinical trials;
Qingpeng ointment
- From:
Chinese Journal of Dermatology
2011;44(12):838-841
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of Qingpeng ointment in the treatment of eczema.Methods A multi-center,randomized,double-blind and placebo-controlled clinical trial was conducted.A total of 246 patients with eczema were randomly assigned with a ratio of 2∶1 to the treatment group and control group to topically apply Qingpeng ointment and placebo respectively twice daily for 3 weeks.Total symptom scores were calculated for the patients at the baseline,on week 1,2 and 3 during the treatment according to the individual scores for pruritus,lesions including erythema,papules,papulovesicles or vesicles,desquamation,crusting,infiltration and lichenification.The occurrence of adverse events was recorded.Results Totally,228 patients completed the trial,including 154 patients in the treatment group and 74 patients in the control group.After 3 weeks of treatment,a statistical difference was observed in the response rate (85.71％ vs.41.89％,Z=47.16,P＜ 0.01) and cure rate (31.82％ vs.12.16％,Z=12.30,P＜ 0.01) between the treatment and control group.There was no significant difference in the incidence of adverse events between the two groups (2.48％ vs.2.56％,x2 =0,P ＞ 0.05).Conclusion Qingpeng ointment displays a promising efficacy for the treatment of mild to moderate eczema with a rapid onset and high safety.
