Clinical study on senile abnormal lipid metabolism intervened by LU Zhi-zheng's dampness-removing, turbid-resolving and heart-communicating formula
10.3760/cma.j.issn.1673-4246.2011.12.003
- VernacularTitle:路志正祛湿化浊通心方对老年血脂代谢异常的干预作用研究
- Author:
Yijian YIN
;
Ling FENG
;
Jie LU
;
Wei LI
- Publication Type:Journal Article
- Keywords:
Abnormal metabolism of lipid;
Dampness-removing,turbid-resolving and heart-commuuicating formula
- From:
International Journal of Traditional Chinese Medicine
2011;33(12):1064-1068
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect and safety of treating senile abnormal lipid metabolism with LU Zhi-zheng's dampness-removing,turbid-resolving and heart-communicating formula.Methods 60 patients were randomly divided into a treatment,treated with LU's formula,one dosage per day,and a control group,treated with gypenosides,60mg/tablet,three times per day,with 30 patients in each group.Both groups were treated two therapeutic courses,which were 8 weeks.Results Except HDL-C,other indexes including TC,TG,LDL-C in the treatment group were all obviously improved after the treatment [the statistical values were (5.81 ± 1.70) mmol/L,(3.05±2.30) mmol/L,(3.39± 1.11 ) mmol/L respectively,P＜0.01 or 0.05],which were also better than the control group [the statistical values were ( 6.16 ± 1.91 ) mmol/L,( 3.03 ± 1.89 ) mmol/L,(3.81±0.63) mmol/L,P＜0.01 or 0.05].Symptoms improvement such as chest oppression,dizziness,heaviness of head,headache,sticky mouth without thirsty,constipation,nausea and vomiting,and heaviness of limbs in the treatment group were also better than the control group,with mean rank were 23.83、38.10、36.10、34.70、36.77、39.82、33.38、34.17 respectively.No abnormal changes were found in indexes of blood routine,urinary routine,stool routine,ECG,ALT,AST and Cr.Conclusion LU Zhi-zheng's dampness-removing,turbid-resolving and heart-communicating formula improved clinical symptoms and signs of abnormal lipid metabolism patients,its therapeutic effects were better than gypenosides.
