Factors related to the therapeutic efficacy of 131 Ⅰ in Graves' disease
10.3760/cma.j.issn.1000-6699.2011.12.004
- VernacularTitle:影响Graves病131Ⅰ疗效的因素分析
- Author:
Xinjian ZHOU
;
Yuan ZHAO
;
Yulian ZHU
;
Yingchun ZHU
;
Lai WEI
- Publication Type:Journal Article
- Keywords:
Graves' disease;
Iodine radioisotopes;
Radionuclide imaging;
Ultrasonography;
Thyroid weight
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(12):975-978
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the efficacy of 131 Ⅰ treatment in Graves' disease,and to analyze the related factors.MethodIn 87 patients with Graves' disease,thyroid uptake ratio( TUR ) and its effective half-life(EHL) were compared before and after 131 Ⅰ treatment.The weight of thyroid gland was evaluated with radio-imaging and type B ultrasonography.ResultThe dose of 131 Ⅰ was ( 185.2 ± 148.0 ) MBq.The TUR of tracer dose and therapeutic 131 Ⅰ dose were 76.5 ％ ±8.2％ and 73.3 ％ ±9.0％ ( t =2.451,P =0.008 ).The EHL were ( 5.2±0.7 ) and ( 5.0 ±0.8 )days,respectively ( t =1.998,P =0.023 ).After followe-up of ( 57.0 ±26.3 ) months,49 patients ( 56.3 ％ ) became euthyroid,14 ( 16.1％ )manifested delayed hypothyroidism,and 24 (27.6％)remained in hyperthyroidism.Thyroid autoantibodies were found in 34.5％ patients,of whom,the incidence of hypothyroidism was higher in patients with positive autoantibodies than those with negative ones (30.0％ vs 8.8％,x2 =6.560,P =0.009 ).ConclusionBoth TUR and EHL of therapeutic doses of 131 Ⅰ are lower than the tracer doses.Positive thyroid autoantibodies may affect the outcome of the 131 Ⅰ treatment.
