The impact of maternal thyroid diseases on the pregnant outcome in the first trimester of pregnancy
10.3760/ema.j.issn.1000-6699.2011.11.011
- VernacularTitle:妊娠早期母体甲状腺功能及其抗体异常对妊娠结局的影响
- Author:
Jianxin LI
;
Sen WANG
;
Zhongyan SHAN
;
Weiwei WANG
;
Weiping TENG
- Publication Type:Journal Article
- Keywords:
Pregnancy;
Thyroid function;
Thyroid autoantibody spontaneous;
Abortion;
Obstetric complications
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(11):916-919
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between maternal thyroid diseases in the first trimester of pregnancy and obstetric complications.Methods A total of 2 517 pregnant women from 10 hospitals in Shenyang during the first 12 weeks of gestation were enrolled in this study.All sera obtained from pregnant women were measured for thyroid-stimulating hormone (TSH),free thyroxine ( FT4 ),and thyroid peroxidase antibody (TPOAb).Collected items include obstetric outcomes and complications.Results Serum TSH above 2.5 mlU/L during the first trimester of pregnancy increased the rate of spontaneous abortion ( 8.69％ vs 6.38％,P =0.048 ),even if subclinical hypothyroidism (9.50％ vs 6.38％,P =0.009).TSH above the gestational special reference range,passive smoking,and over 30 years were independent factors for increasing the rate of spontaneous abortion.Hyperthyroidism and hypothyroidism with drug treatment to maintain normal thyroid function during pregnancy reduced the incidence of spontaneous abortion.Increased or decreased levels of serum TSH and TPOAb(+) were not related with other obstetric complications.Conclusion Serum TSH above the gestational special reference range during the first trimester of pregnancy is a risk factor of spontaneous abortion; maintaining TSH within the normal range by treating hyperthyroidism or hypothyroidism may reduce spontaneous abortion rate.
