Expressions of estrogen receptor β1 and β2 in human thyroid neoplasms and its clinical implication

VernacularTitle:甲状腺肿瘤组织中雌激素受体β1和β2的表达及其意义
Author: Dongling JIN ; Lei WANG ; Feng XI ; Lianxiang LI ; Ke TIAN
Publication Type:Journal Article
Keywords: Thyroid neoplasms; Estrogen receptor
From: Chinese Journal of Endocrinology and Metabolism 2011;27(11):932-934
CountryChina
Language:Chinese
Abstract: The expressions of estrogen receptor (ER) α,ERβ1,and ERβ2 in thyroid carcinoma,thyroid adenoma,and adjacent normal thyroid tissue were determined by RT-PCR and immunohistochemistry,and the relationship of expression levels of three ERs and the main clinical pathologic parameters were evaluated.The result showed that ERα mRNA expression in papillary thyroid carcinoma(PTC) tissues was significantly higher than adjacent normal tissue,while,ERβ2 mRNA expression in PTC tissues was significantly lower than normal tissue ( P＜0.05 ).The positive expression of ERβ1 and ERβ2 in the thyroid carcinoma was related with the histological variant of carcinomas; the ERβ2 expressions were related with the lymph node metastasis and TNM staging of the carcinomas.These results suggest that the decreased ERβ2 expression may induce proliferation and carcinogenesis of thyroid follicular epithelial cells as well as progression of the carcinoma,and is a powerful prognostic indicator.