Effect of breviscapine on lung injury in children undergoing open heart surgery with cardiopulmonary bypass
10.3760/cma.j.issn.0254-1416.2011.09.022
- VernacularTitle:灯盏花素对CPB下心内直视手术患儿肺损伤的影响
- Author:
Jun CHEN
;
Yinghua ZHAO
;
Xiulan LIU
;
Xiaoling CHEN
;
Boxi XIA
;
Jun LI
;
Qingquan LIAN
;
Wangning SHANGGUAN
- Publication Type:Journal Article
- Keywords:
Flavonoids;
Cardiopulmonary bypass;
Cardiac surgical procedures;
Respiratory distress syndrome,adult;
Child
- From:
Chinese Journal of Anesthesiology
2011;31(9):1106-1109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of breviscapine on lung injury in children undergoing open heart surgery with cardiopulmonary bypass(CPB).Methods Forty-five ASA Ⅱ or Ⅲ children aged 3-65 months weighing 5-21 kg undergoing open heart surgery with CPB were randomly assigned to 3 groups ( n =15 each):control group (group C),low dose breviscapine group (group B1 ) and high dose breviscapine group (group B2).Normal saline 15 ml(group C),breviscapine 0.5 mg/kg (group B1 )or 1.0 mg/kg(group B2 ) were injected iv over 30min after anesthesia induction.Blood samples were taken before operation ( T0 ),at 30 min and 1 h of aortic unclamping (T1,T2 ),at 3 h and 6 h after operation (T3,T4 ) for determination of plasma procalcitonin (PCT)and neutrophil elastase(NE) concentrations.PaO2 and PaCO2 were recorded at T0,T3,T4 for caculation of oxygenation index (OI) and alveolo-arterial oxygen partial pressure difference (PA-a O2 ).Results There were no significant differences in OI and PA-a O2 among the 3 groups( P ＞ 0.05).Plasma concentration of PCT was higher at T1～4in 3 groups,and plasma concentration of NE was higher at T1 in group C than that at T0 ( P ＜ 0.01 ).Plasma concentrations of PCT and NE were lower in groups B1 and B2 than in group C ( P ＜ 0.01).There were no significant differences in plasma concentrations of PCT and NE between groups B1 and B2 ( P ＞ 0.05).Conclusion Breviscapine(0.5,1 mg/kg) can inhibite systemic inflammatory response and attenuate lung injury in children undergoing open heart surgery with CPB.
