Comparison of hematopoietic stem cell transplantation from HLA identical siblings vs intensive immunosuppression therapy for severe aplastic anemia

VernacularTitle:亲缘全相合HSCT与强化免疫抑制治疗再生障碍性贫血的疗效比较
Author: Yin XIAO ; Yong YOU ; Zhaodong ZHONG ; Linghui XIA ; Mei HONG ; Ping ZOU
Publication Type:Journal Article
Keywords: Anemia,aplastic; Therapy; Hematopoietic stem cell transplantation; Immunosuppression
From: Chinese Journal of Organ Transplantation 2011;32(12):738-740
CountryChina
Language:Chinese
Abstract: Objective To retrospectively analyze and compare the curative outcome of hematopoietic stem cell transplantation (HSCT) from HLA identical siblings vs intensive immunosuppression therapy (IST) for severe aplastic anemia (SAA).Methods From January 2008 to December 2010,41 patients with severe aplastic anemia were treated with related HSCT (n =14) or IST (n =27) which combined antithymocyte globulin (ATG) with cyclosporine-A (CsA) therapy.Results All the patients receiving HSCT reached complete response.Among the patients receiving IST,21 patients could be responsive to the therapy,and 2 patients died.There was significant difference in the response rate between HSCT group and IST group (100 ％ vs 77.8 ％,P＜0.01 ).Conclusion With the improvement of HSCT technology,the curative outcome of HSCT from HLA identical siblings for SAA is much better than IST.