Treatment of multiple myeloma complicating femoral neck fracture
10.3760/cma.j.issn.1673-4904.2011.35.008
- VernacularTitle:多发性骨髓瘤合并股骨颈骨折的治疗
- Author:
Hongyan LIU
;
Yunxiang XIAO
;
Jingming GUO
;
Haiyan WANG
;
Song YE
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Femoral neck fractures;
Total hip arthroplasty;
Drug therapy
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(35):21-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect on treatment of multiple myeloma complicating femoral neck fracture by surgical intervention combined with drugs.Methods Twelve patients with multiple myeloma complicating femoral neck fracture were treated by cemented total hip arthroplasty femoral head shank.All of patients were received zoledronic acid treatment,at the same time,7 cases of them treated by MPT regimen (melphalan,methylprednisolone and thalidomide),3 by bortezomib combined with dexamethasone,and 1 by autologous peripheral blood stem cell transplantation.Results Twelve patients could tolerate surgery,postoperative pain was significantly reduced.Assessed by using Harris hip function score after 6 months operation,2 cases were excellent,7 cases were good,3 cases were common,excellent and good rate was 75％ (9/12).All patients were followed up for 8 months to 3 years,1 case of local recurrence after 13 months.1-year overall survival rate was 100％,2-year overall survival rate was 83％,and 3-year overall survival rate was 67％.Conclusions Multiple myeloma complicating femoral neck fracture,using bone cement in total hip arthroplasty femoral head shank to clear the local tumor lesions,receive reconstruction capability,rapid postoperative recovery,pain relief,and opportunities for further comprehensive treatments.The bisphosphonate can promote new bone formation and prevent further fractures.The surgical intervention combined with chemotherapy could relieve the symptoms,reduce tumor cell burden,improve quality of life and prolong survival time.
