Comparison of virological response between Peg IFNα-2a and Peg IFNα-2b in treatment of chronic hepatitis C
10.3760/cma.j.issn.1674-2397.2011.06.008
- VernacularTitle:慢性丙型肝炎患者应用聚乙二醇干扰素α-2a和2b病毒学应答比较
- Author:
Rangxiao ZHUANG
;
Hongping ZHOU
;
Weifeng LIANG
;
Yidan SHAO
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis C;
Inferferons;
Ribavirin;
Virological response
- From:
Chinese Journal of Clinical Infectious Diseases
2011;04(6):355-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the virological responses between Peg IFNαt-2a and Peg IFNα-2b in treatment of chronic hepatitis C.Methods Clinical data of 46 chronic hepatitis C (CHC) patients were retrospectively reviewed.Patients were divided into two groups:Peg IFNα-2a group ( n =24) was given Peg IFNoα-2a 180 μg/week and ribavirin; Peg IFNα-2b group (n =22 ) was given Peg IFNα-2b1.5 μg · kg-1 · week-1 and ribavirin.Serum HCV RNA load at 4th,12th and 24th week of the treatment were detected to evaluate the virological responses.Softwares SPSS 13.0 and PEMS 3.1 were used for statistical analysis.Results There was no significant difference in rapid response rate,early response rate,complete response rate and non-response rate between the two groups (x2 =0.689,0.105,0.105 and 0.105,P ＞ 0.05 ).However for patients with high viral load ( HCV RNA ＞ 6 logl0 copies/mL) at baseline,the rapid response rate in Peg IFNα-2a group ( 86.67％ ) was higher than that in Peg IFNα-2bgroup (42.86％ ) (x2 =4.365,P ＜ 0.05 ).Conclusion Peg IFNα-2a combined with ribavirin may have higher rapid response rate than that of Peg IFNα-2b combined with ribavirin in CHC patients with high viral
