Clinical study of small dose reteplase thrombolytic therapy on old patients with acute myocardial infarction
10.3760/cma.j.issn.1673-4904.2011.36.007
- VernacularTitle:小剂量瑞替普酶溶栓疗法治疗老年急性心肌梗死的临床研究
- Author:
Lu ZHU
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Aged;
Reteplase
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(36):15-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of small dose reteplase thrombolytic therapy on old patients with acute myocardial infarction(AMI).Methods Eighty-two old patients with AMI were divided into two groups by random digits table,each group had 41 cases.Control group was treated with recombinant streptokinase,and observation group was treated with small dose reteplase.The clinical effect,1 h and 2 h coronary artery recanalization rates between two groups were compared.Results After treatment 24 h,there was no significant difference in total effective rate and death rate between two groups(P＞ 0.05).The 1 h and 2 h coronary artery recanalization rates in observation group were significantly higher than those in control group[56.1％(23/41)vs.26.8％(11/41),63.4％(26/41)vs.39.0％(16/41)](P＜ 0.05).The mild bleeding incidence in observation group was significantly higher than that in control group(P ＜ 0.05),while there was no significant difference between two groups in severe bleeding incidence(P ＞ 0.05).Conclusion Small dose reteplase thrombolytic therapy on old patients with AMI is effective,which provide a safe and effective method for elderly patients unwilling or unable to accept the coronary angioplasty.
