Comparison of preventive effects of tramadol and ketamine on remifentanil-induced postoperative hyperalgesia after neurosurgical anesthesia
10.3760/cma.j.issn.1673-4904.2011.33.001
- VernacularTitle:曲马多与氯胺酮预防雷米芬太尼麻醉颅脑手术患者术后痛觉过敏效果的比较
- Author:
Huiwen WANG
;
Xuemei ZHANG
;
Chunmei HOU
;
Ruquan HAN
- Publication Type:Journal Article
- Keywords:
Tramadol;
Ketamine;
Hyperalgesia;
Neurosurgical procedures
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(33):1-4
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the preventive effects oftramadol and ketamine on the patients with postoperative hyperalgesia after remifentanil-induced neurosurgical anesthesia.MethodsOne hundred and fifty patients undergoing craniotomy were assigned to tramadol group,ketamine group and normal saline group with 50 cases each by random digits table.Anesthesia was maintained with infusion of remifentanil [0.1-0.2μ g/( kg· min ) ],propofol and sevoflurane.Tramadol ( 1.5 mg/kg),ketamine (0.5 mg/kg) or normal saline was given before skin closing.The emergence time,trachea extubation time,patients required analgesia and tramadol consumption,reverse effect were recorded.The visual analog scale (VAS),Ramsay scores at 15,30,60,120 minutes after emergence were performed.ResultsPatients required analgesia and tramadol consumption in tramadol group and ketamine group were significantly lower than those in normal saline group (P ＜0.01 or ＜0.05 ).The occurrence of shiver in tramadol group was lower than that in normal saline group (P ＜0.05).VAS scores in tramadol group at 15,30 minutes and in ketamine group at 30 minutes after emergence were significantly lower than those in normal saline group (P＜ 0.05).Ramsay score in ketamine group at 15 minutes after emergence was higher than that in tramadol group and normal saline group [ (2.9 ±0.6) scores vs.(2.3 ±0.7) scores and (2.3 ±0.9) scores](P＜0.01).ConclusionTramadol has a goodpreventive effect for postoperative hyperalgesia induced by remifentanil in neurosurgery compared with ketamine.
