Analgesic efficacy of parecoxib in total knee arthroplasty and total hip arthroplasty surgery
10.3760/cma.j.issn.1001-8050.2011.12.010
- VernacularTitle:帕瑞昔布钠对全膝全髋关节置换术后镇痛的疗效分析
- Author:
Chengfang HU
;
Yunsu CHEN
;
Qi WANG
;
Hao SHEN
;
Wenjun DONG
;
Xianlong ZHANG
- Publication Type:Journal Article
- Keywords:
Arthroplasty,replacement;
Knee joint;
Hip joint;
Analgesia;
Parecoxib
- From:
Chinese Journal of Trauma
2011;27(12):1090-1095
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the analgesic effect of parecoxib in total knee arthroplasty (TKA) and total hip arthroplasty (THA).Methods The study was a prospective,randomized and double-blind trial and was operated by the same group of surgeons in 101 patients with TKA and 105 patients with THA.According to analgesic protocol,the patients were divided into three groups:Group One ( intravenous injection with parecoxib),Group Two ( periarticular injection with parecoxib) and Group Three ( the control group).The postoperative visual analog scores (VAS),range of motion ( ROM),the ability of straight leg raising and the incidence of nausea and vomiting complications were examined and compared between the three groups.Results There were no significant differences in VAS (6,12,24,36,48,72 hours after operation),ROM ( 24 hours after operation) and the ability of straight leg raising between Group One and Group Two ( P ＞ 0.05 ),but all of them were significantly higher than those in Group Three ( P ＜ 0.05 ).Nausea,vomiting and other adverse effects did not significandy increase with the use of parecoxib.Conclusions Both intraoperative intravenous injection and periarticular injection with parecoxib have a good analgesia effect on TKA and THA,which are beneficial to the rapid recovery of joint function in patients.The simple and practical method provides an effective adjunct to a multimodal analgetic approach in improving the postoperative course of TKA and THA.
