Relationships between T and NK cells in peripheral blood and the relapse or metastasis of malignant tumors

VernacularTitle:外周血T细胞亚群及自然杀伤细胞监测与恶性肿瘤复发或转移的关系
Author: Jiemin ZHAO ; Liangrong SHI ; Mei JI ; Hongyu ZHANG ; Jun WU ; Aizhen WU ; Changping WU
Publication Type:Journal Article
Keywords: Neoplasm recurrence,local; Neoplasm metastasis; T-lymphocyte subsets; Killer cells,natural; Flow cytometry
From: Chinese Journal of Postgraduates of Medicine 2011;34(34):10-12
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the relationships between T and NK cells in peripheral blood and the relapse or metastasis of malignant tumors.MethodsFlow cytometry was used to test the percentages ofT and NK cells in peripheral blood of 48 malignant tumor patients with relapse or metastasis (relapse or metastasis group) and 48 malignant tumor patients without relapse or metastasis(control group).ResultsCompared with control group,the ratio of Th/Ts decreased,CD4+/CD25+ raised and the activities of NK cells decreased in relapse or metastasis group (0.95 ±0.52 vs.1.35 ±0.43,7.15 ±3.81 vs.6.01 ±2.67,0.2053 ±0.1135 vs.0.2501 ±0.0745)(P＜0.01 or ＜0.05).ConclusionsTesting the T and NK cells in peripheral blood of malignant tumor patients regularly can know their immune status and find the relapse or metastasis early.It is easy and useful in patients' follow-up.