Research advances of Six1 gene in breast cancer
10.3760/cma.j.isan.1673-4203.2011.12.014
- VernacularTitle:Six1基因在乳腺癌中的研究进展
- Author:
Wangfeng LU
;
Xiaobin MA
;
Xijing WANG
- Publication Type:Journal Article
- Keywords:
Six1;
Epithelial- mesenchymal transition;
Overexpression;
Breast neoplasms
- From:
International Journal of Surgery
2011;38(12):832-835
- CountryChina
- Language:Chinese
-
Abstract:
Homeobox gene Six1,as a transcription factor has been proved to participate in most malignant tumors.Its overexpression is associated with the genesis and development of breast cancer intimately.Overexpression of Six1 in mammary cells is sufficient to induce activation of stem cells.Similarly,Six1-overexpressed tumors could activate the TGF-β pathway and Wnt/β-catenin pathway,lead to malignant transformation by inducing epithelial-mesenchymal transition and mammary tumorigenesis.Research on the role of sixl will improve understanding the mechanisms of breast cancer initiation and development.
