Clinical study of loading dose of phenobarbital in neonatal hypoxic-ischemic encephalopathy
10.3760/cma.j.issn.1673-4904.2011.36.001
- VernacularTitle:采用负荷量苯巴比妥治疗新生儿缺氧缺血性脑病的临床研究
- Author:
Jun PAN
;
Jiang HU
;
Jijian XIE
;
Tao LI
- Publication Type:Journal Article
- Keywords:
Phenobarbital;
Infant,newborn;
Hypoxia-ischemia;
brain
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(36):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of loading dose of phenobarbital in neonatal hypoxic-ischemic encephalopathy(HIE).Methods Three hundred and fifty-six patients with neonatal HIE were randomly divided into treatment group and control group by systematic sampling,with 178 patients in each group.Two groups were given comprehensive therapy,with or without convalsions,early application of loading dose of phenobarbital in 20 mg/kg intramuscular injection,12 h beck to a maintenance dose 5 mg/(kg·d)in treatment group,while a conventional dose of phenobarbital in 5 mg/(kg·d)was used in control group after convulsion happened.Clinical effect of short-term and long-term were observed.Results The rates of eelampsia,choloplania and total effect was 11.2％(20/178),7.9％(14/178)and 87.1％(155/178)in treatment group,and 68.0％(121/178),50.6％(90/178)and 77.5％(138/178)in control group,there were significant differences between two groups(x2 =6.403,78.459 and 8.308,P ＜ 0.05).DQ score in treatment group was higher than that in control group(P＜ 0.05).The patients in two groups were followed up to age 18 months,the deformity rate in treatment group[7.9％(14/178)]was lower than that in control group[28.1％(50/178)],there was significant difference between two groups(x2 =29.085,P ＜ 0.05).Conclusion Loading dose of phenobarbital is very effective to treat neonatal HIE.
