Diagnosis of bone-metastasis in lung cancer by bone scanning combined with bone alkaline phosphatase detection
10.3760/cma.j.issn.1006-9801.2011.05.009
- VernacularTitle:全身骨显像联合血清骨型碱性磷酸酶诊断肺癌骨转移
- Author:
Jianrong WU
;
Ling ZHENG
;
Hong YANG
;
Juan BAI
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Neoplasm metastasis;
Radionuclide imaging;
Alkaline phosphatase
- From:
Cancer Research and Clinic
2011;23(5):318-320
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the diagnostic value of bone scanning and bone alkaline phosphatase (B-ALP) detection in diagnosis of osseous metastases in lung cancer. Methods 58 patients with lung cancer were examined by bone scanning and serum alkaline phosphates(ALP) and B-ALP detection. The results were analyzed. Results Among the 58 patients, bone scanning found osseous metastases in 33 patients, the incidence was 56.90 %. Among the 58 patients, the incidence of bone metastasis of adenocarcinoma was 70.97 % (22/33) and squamous carcinoma was 42.86 % (9/21) (x2 =4.109, P =0.0427). The incidence of bone metastases increased in B-ALP ≥150 U/L. B-ALP was significantly correlated with the number of metastatic loci in bone. The sensitivity of bone scanning is the highest (93.94 %), but specificity the lowest (92.00 %).The sensitivity combining bone scanning and B-ALP is the lowest (57.58 %), but the specificity the highest (100.00 %). Conclusion Whole-body bone scanning has high sensitivity in early detection of bone metastases. For diagnosis of osseous metastases in patients with lung cancer, bone scanning is the primary choice. Combining the bone scanning with B-ALP can increase specificity. B-ALP has certain using value to confirm bone metastasis and decide the disease extent.
