Expression and clinical significance of Survivin in cervical cancer

VernacularTitle:Survivin在子宫颈癌中的表达及其临床意义
Author: Zhetao MI ; Wei LIU ; Shumin ZHENG
Publication Type:Journal Article
Keywords: Uterine cervical neoplasms; Inhibitor of apoptosis proteins; Survivin genein; Immunohistochemical method
From: Cancer Research and Clinic 2010;22(z1):36-37
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of Survivin gene and the relationship between Survivin and genesis and development of cervical cancer. Methods The expression of Survivin gene in tissues of 40 patients with cervical cancer, 38 patients with cervical hyperplasia and 10 cases of normal cervical were detected by immunohistochemical SP method, and the relationships between Survivin and the clinical pathological factors were analyzed. Results The expression positive rate of Survivin in cervical cancer tissues (60 %) was significantly higher than that in cervical hyperplasia and normal cervical tissues (42.1 % and 0, respectively), and their differences were statistically significant (P < 0.05). The positive expression rate of Survivin was related with histological grade and the clinical stages of cervical cancer.Conclusion Survivin is related to the genesis and development of cervical cancer.