Expression and clinical significance of matrix metalloproteinase-3 and osteopontin in cervical carcinoma

VernacularTitle:基质金属蛋白酶-3和骨桥蛋白在子宫颈癌组织中的表达及其临床意义
Author: Wei LIU ; Shumin ZHENG
Publication Type:Journal Article
Keywords: Uterine cervical neoplasms; Matrix metalloproteinase-3; Osteopontin; Immunohistochemistry
From: Cancer Research and Clinic 2010;22(z1):29-31
CountryChina
Language:Chinese
Abstract: Objective To study the expressions of matrix metalloproteinase-3 (MMP-3) and osteopontin (OPN) in cervical carcinoma and their relationship with invasion and metastasis. Methods The expression of MMP-3 and OPN were detected in 54 cases of cervical cancer tissues by immunohistochemical SP method. Compared with 15 cases of normal cervical tissues, the relationship was analyzed between both protein expressions and clinical pathology. Results The expression positive rates of MMP-3 and OPN in cervical cancer tissues (70.37 % and 66.7 %, respectively) were significantly higher than those of normal cervical tissues (20 % and 0, respectively), were significantly higher with infiltration depth >1/2 and lymph node metastasis than those with depth≤1/2 and without metastasis , respectively(P <0.05). The expressions of MMP-3 and OPN were related with depth of cervical infiltration and lymph node metastasis of cervical cancer.Expressions between MMP-3 and OPN were significantly positively correlation(r =0.401, P<0.05). Conclusion The expressions of MMP-3 and OPN are correlated with invasion and metastasis of cervical carcinoma.