The expression and significance of MMP-9 and Survivin in ovarian cancer
10.3760/cma.j.issn.1006-9801.2010.增.008
- VernacularTitle:Survivin和基质金属蛋白酶-9基因在卵巢癌中的表达及其临床意义
- Author:
Zhongying HAN
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Matrix metalloproteinase 9;
Survivin
- From:
Cancer Research and Clinic
2010;22(z1):23-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of MMP-9 and Survivin in ovary cancer and investigate their relationship in local invasion, genesis and development of ovarian cancer. Methods The tissues samples from 64 cases of epithelial ovarian cancer,30 cases of carcinoid, 11 cases of borderline tumor and 20 cases of normal were collected, expressions of MMP-9 and Survivin were detected by immuohistochemistry SP method and RT-PCR. Results The expression positive rates of Survivin were 20.00 %, 20.00 %, 36.67 % and 76.56 %, and the positive rates of MMP-9 were 25.00 %, 23.33 %, 45.45 % and 79.68 % in normal ovarian tissues, carcinoid, borderline tumor and epithelial cancer of ovary, respectively. The positive rates of MMP-9 and Survivin were were higher in ovary epithelial cancer carcinoid than those in carcinoid and normal ovarian tissues(P <0.05). The mRNA of Survivin were (0.21 ±0.03), (0.19± 0.05), (0.38±0.02) and (0.58±0.02), and the mRNA of MMP-9 were (0.23±0.03), (0.21±0.05), (0.44±0.02) and (0.59±0.04) in normal ovarian tissues, carcinoid, borderline tumor and epithelial cancer of ovary, respectively.The mRNA levels of Survivin and MMP-9 were higher in carcinoid and epithelial cancer of ovary than those in normal ovarian tissues. Conclusion The over expressions of Survivin and MMP-9 are related to genesis and development of ovarian cancer.
