Expression of osteopontin in local tissues of patients with cervical cancer

VernacularTitle:骨桥蛋白在子宫颈鳞癌患者局部组织中的表达
Author: Xiaoling SUN ; Weihong YAO ; Qingping WEI ; Yahong FU ; Feng FENG
Publication Type:Journal Article
Keywords: Osteopontin; Chronic cervicitis; Cervical intraepithelial neoplasia; Cervical cancer
From: Cancer Research and Clinic 2010;22(z1):11-13
CountryChina
Language:Chinese
Abstract: Objective To detect the expression of osteopontin (OPN) in cervical local tissues of patients with chronic cervicitis, cervical intraepithelial neoplasia (CIN), cervical cancer. To investigate the possibility that OPN is used as tumor marker of cervical cancer. Methods The expression of OPN in 25 cases of chronic cervicitis, 18 cases of CIN and 21 cases of cervical cancer was detected by immuohistochemistry SP method. Results The positive expression rates of OPN in the chronic cervicitis, CIN and the cervical cancer had a rising trend (48 %, 77.78 % and 80.95 %, respectively) and their differences had statistical significant (P <0.05). The OPN expression level in cervical cancer had no statistical correlation with age, tumor size, clinical stage and other clinical pathological features (P >0.05). Although OPN expression level in cervical cancer wasn' t related with tumor clinical stage, positive expression rates of OPN had a gradually increased trend along with the clinical stage. Conclusion High expression of OPN is found in cervical cancer and may be related to the occurrence and development of cervical cancer.