Relationship between polymorphism of arylamine N-acetyltransferase 2 and genetic susceptibility to hair dye dermatitis
10.3760/cma.j.issn.1671-0290.2011.03.010
- VernacularTitle:N-乙酰基转移酶2基因多态性与染发皮炎易感性关系
- Author:
Qiuyan YANG
;
Hongjun XU
;
Yuanjun LIU
;
Weifeng YAO
;
Quanzhong LIU
- Publication Type:Journal Article
- Keywords:
Hair dye dermatitis;
Arylamine N-acetyltransferase 2 (NAT2);
Polymorphism
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2011;17(3):190-193
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between polymorphism of arylamine N-acetyltransferase 2 (NAT2) and hair dye dermatitis in a Chinese population. Methods Polymorphism chain-restriction fragment length polymorphism (PCR-RFLP) was used and the wild-type allele (NAT2 * 4) and three mutant alleles (NAT2 * 5A, 6B and 7A) were determined in 60 patients with hair dye dermatitis and 73 age-matched control subjects in Tianjin region. Results In hair dye dermatitis cases, the frequency of NAT2 * 4, NAT2 * 5A, NAT2 * 6B, NAT2 * 7A was 52. 5 % , 5. 0 % ,26.7 % and 15. 8 %, respectively, and no statistically significant difference of the frequencies was found between the hair dye dermatitis patients and controls (P>0. 05). The frequency of rapid genotype, intermediate genotype and slow genotype was 26. 7 % , 51. 7 % and 21. 7 % in hair dye dermatitis cases, 30. 1 %, 50. 7 % and 19. 2 % in control subjects, respectively, and no statistically significant difference of the frequencies between the two groups (P>0. 05). Conclusions Our study suggests that there might be no relationship between polymorphism of NAT2 and genetic susceptibility to hair dye dermatitis in a Chinese population.
