Pathogenesis of keloids and its related factors of recurrence: a clinical analysis of 476 cases
10.3760/cma.j.issn.1671-0290.2011.03.004
- VernacularTitle:瘢痕疙瘩发病及治疗后复发的临床相关因素分析
- Author:
Xiaomei ZHAI
;
Ken QIN
;
Linbo LIU
;
Minjing CHEN
;
Wei WANG
- Publication Type:Journal Article
- Keywords:
Keloids;
Clinical study;
Pathogenesis;
Recurrence factors
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2011;17(3):171-173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study what affect the incidence and recurrence of keloids. Methods A total of 476 cases were treated with surgery plus adjunctive radiation therapy, intraleisional injection of triamcinolone acetonaide acetate, or surgery plus postoperative topical medicine. The family history and other clinical data were analyzed, including patients' age, sex, the duration of keloids, initiating factors, location, size, treatment method, and recurrence of the keloids. Results Keloids occurred in both male and female with the rate of 1. 83 ∶ 1. 00, with a predominance in woman aged from 22 to 45 years old. Trauma and pierce were the most significant initiating factors. The recurrence was affected by patients family history, treatment methods and the location of keloids, and less affected by keloids size, patients' age and sex. Conclusions Both surgery following adjunctive radiation therapy and intraleisional Kenalog injection are useful methods, which are prior to surgery plus postoperative topical medicine. The keloids incidence has a preponderance in some patients with family history. Therefore,genetic research is important to identify the pathogenetic factors in the keloids.
