The application of plasma drug monitoring in pediatric HIV/AIDS patient antiretroviral therapy adherence monitoring
10.3760/cma.j.issn.1009-9158.2011.06.016
- VernacularTitle:血药浓度监测在儿童艾滋病患者抗病毒治疗依从性评价中的应用
- Author:
Xia LIU
;
Yan ZHAO
;
Yuewu CHENG
;
Weiwei MU
;
Xin SUN
;
Chunming LI
;
Fujie ZHANG
- Publication Type:Journal Article
- Keywords:
Pediatric;
HIV;
Antiretroviral therapy;
Therapeutic drug monitoring;
Adherence
- From:
Chinese Journal of Laboratory Medicine
2011;34(6):542-545
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the application of plasma drug monitoring in pediatric HIV/AIDS patient antiretroviral therapy adherence monitoring.Methods Totally 261 plasma samples and related information were collected from three consecutive follow-up visits of 87 HIV-infected children treated in Shangcai county CDC of Henan province from March to October 2009.The plasma concentrations of antiretroviral drugs were measured by a developed high performance liquid chromatography-mass spectrometry method.Potential adherence influencing factors, such as regimen, age, gender, parent conditions, previous ART exposure and therapy duration, were analyzed by univariate logistic regression.Results Plasma concentration of antiretroviral drugs lower than LLTR (1 000 ng/ml) was the criteria to identify missed dose.The concentrations of 28 plasma samples were lower than LLTR, which meant missing dose.There were 17 patients (19.5%) with their concentrations lower than LLTR at least once in three follow-up visits.Logistic regression analysis of adherence related factors showed that compared with the children whose parents were both alive, the children whose mother and (or) father died were more likely to miss dose.The odds ratio was 4.13(95% credibility interval:1.37-12.46, P values was 0.012).Conclusions HIV-infected children have adherence problems when receiving antiretroviral therapy.Plasma therapeutic drug monitoring can be one of the effective methods to monitor the adherence.
