Effects of potassium concentration and ion channel conductance on spontaneous firing of Hippocampal CA1 neuron
10.3760/cma.j.issn.1673-4181.2011.02.006
- VernacularTitle:钾离子浓度及离子通道电导对海马CA1区神经元自发放电的影响
- Author:
Nan XIE
;
Qingli QIAO
- Publication Type:Journal Article
- Keywords:
Hippocampal CA1;
Spontaneous firing;
Spiking frequency;
Burst model
- From:
International Journal of Biomedical Engineering
2011;34(2):86-90
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the variability of spontaneous firing frequencies and firing patterns of a Hippocampal CA1 neuron with the changes of extracellular potassium concentration[K+]0 and ion channel conductance.Methods A 16-compartment cable model of a Hippocampal CA1 neuron was developed based on the Warman model with computer software MATLAB.The dendrites contained no active channels,while five active channels (INa,INap,IDR,IA,IM)were contained in soma.In the model,the calcium currents and potassium currents(ICm,,ICT and IAHP) regulated by calcium concentration were not included.ResultsSimulation results showed that the neuron could generate periodicspontaneous firing activity.The spiking frequency increased with the increasing of[K+]0 and sodium conductance and decreasing of potassium conductance.Spontaneous single neuron activity appeared in singlet or in grouped bursts of two or three spikes.Conclusion The variability of spontaneous firing frequencies and firing patterns of single neuron are relevant to[K+]0 and ion channel conductance.
